ΠΡΡΠ³ΠΈΠ΅ ΡΠ²Π΅Π΄Π΅Π½ΠΈΡ, ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Π½ΡΠ΅ Π² ΡΡΠΎΠΉ Π³Π»Π°Π²Π΅, ΠΏΠΎΡΠ΅ΡΠΏΠ½ΡΡΡ ΠΈΠ· ΡΠ»Π΅Π΄ΡΡΡΠΈΡ ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠ²:
Buck, L. & R. Axel. Novel multigene family may encode odorant receptors: A molecular basis for odor recognition. Cell 65, no. 1 (1991): 175β187.
Jacob, F. The Statue Within. Translated by F. Philip. New York: Basic Books, 1988.
Kandel, E. R., A. Kriegstein & S. Schacher. Development of the central nervous system of Aplysia in the terms of the differentiation of its specific identifiable cells. Neuwsci. 5 (1980): 2033β2063.
Scheller, R. H., J. F. Jackson, L. B. McAllister, J. H. Schwartz, E. R. Kandel & R. Axel. A family of genes that codes for ELH, a neuropeptide eliciting a stereotyped pattern of behavior in Aplysia. Cell 28 (1982): 707β719; ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Π½Π°Ρ ΡΠΈΡΠ°ΡΠ° β ΡΡΡ. 707.
Weinberg, R. A. Racing to the Beginning of the Road: The Search for the Origin of Cancer. San Francisco: Freeman, 1998; ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Π½Π°Ρ ΡΠΈΡΠ°ΡΠ° β ΡΡΡ. 162β163.
19. ΠΠΈΠ°Π»ΠΎΠ³ Π³Π΅Π½ΠΎΠ² ΠΈ ΡΠΈΠ½Π°ΠΏΡΠΎΠ²
ΠΠ²Π΅ ΠΎΠ±Π·ΠΎΡΠ½ΡΠ΅ ΡΡΠ°ΡΡΠΈ Π€ΠΈΠ»ΠΈΠΏΠ° ΠΠ΅Π»Π΅ΡΠ°: P. Goelet, V. Castellucci, S. Schacher & E. R. Kandel, The long and short of long-term memory β a molecular framework, Nature 322 (1986): 419β422 ΠΈ P. Goelet & E. R. Kandel, Tracking the flow of learned information from membrane receptors to genome, Trends Neurosci. 9 (1986): 472β499.
Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΠ΅ΡΠ΅ΠΌΠ΅ΡΠ΅Π½ΠΈΡ ΡΠΠΠ€-Π·Π°Π²ΠΈΡΠΈΠΌΠΎΠΉ ΠΏΡΠΎΡΠ΅ΠΈΠ½ΠΊΠΈΠ½Π°Π·Ρ Ρ Π½Π°ΠΌΠΈ Π±ΡΠ» Π ΠΎΠ΄ΠΆΠ΅Ρ Π¦ΡΠ½Ρ, ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊ ΠΠ½ΡΡΠΈΡΡΡΠ° ΠΠΎΠ²Π°ΡΠ΄Π° Π₯ΡΡΠ·Π° ΠΈΠ· ΠΠ°Π»ΠΈΡΠΎΡΠ½ΠΈΠΉΡΠΊΠΎΠ³ΠΎ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠ° Π² Π‘Π°Π½-ΠΠΈΠ΅Π³ΠΎ, ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π²ΡΠΈΠΉ ΠΌΠ΅ΡΠΎΠ΄, ΠΊΠΎΡΠΎΡΡΠΌ ΠΌΡ Π²ΠΎΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈΡΡ, ΡΡΠΎΠ±Ρ ΠΎΡΡΠ»Π΅Π΄ΠΈΡΡ ΠΏΠΎΡΡΡΠΏΠ»Π΅Π½ΠΈΠ΅ ΡΠΠΠ€-Π·Π°Π²ΠΈΡΠΈΠΌΠΎΠΉ ΠΏΡΠΎΡΠ΅ΠΈΠ½ΠΊΠΈΠ½Π°Π·Ρ Π² ΡΠ΄ΡΠΎ. ΠΡΠ° ΡΠ°Π±ΠΎΡΠ° ΠΎΠΏΠΈΡΠ°Π½Π° Π² ΡΡΠ°ΡΡΠ΅: Π. J. Bacskai, Π. Hochner, Π. Mahaut-Smith, S. R. Adams, Π. Π. Kaang, E. R. Kandel & R. Y. Tsien , Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons, Science 260 (1993): 222β226.
ΠΠ½ΠΈΡΠΈΠ°ΡΠΎΡΠΎΠΌ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΠΊΡΠ»ΡΡΡΡ Π΄Π»Ρ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠΎΠ² Ρ Π½Π΅ΠΉΡΠΎΠ½Π°ΠΌΠΈ Π°ΠΏΠ»ΠΈΠ·ΠΈΠΈ Π±ΡΠ» Π‘ΡΠΌ Π¨Π°Ρ Π΅Ρ, Ρ ΠΊΠΎΡΠΎΡΡΠΌ ΡΠΎΡΡΡΠ΄Π½ΠΈΡΠ°Π»ΠΈ ΠΌΠΎΠΈ ΡΡΠ΅Π½ΠΈΠΊΠΈ Π‘ΡΠΈΠ²Π΅Π½ Π Π΅ΠΉΠΏΠΎΡΡ, ΠΡΠ΅Ρ ΠΠΆΠΎΡΠ΄ΠΆΠΎ ΠΠΎΠ½ΡΠ°ΡΠΎΠ»ΠΎ ΠΈ ΠΡΠΈΠΊ ΠΡΠΎΡΠ°Π½ΡΠΊΠΈ.
ΠΠ΅ΡΠ²ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΎ ΡΠΎΠ»ΠΈ CREB-Π±Π΅Π»ΠΊΠ° Π² ΡΠΈΠ½Π°ΠΏΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠ»Π°ΡΡΠΈΡΠ½ΠΎΡΡΠΈ, ΡΠ²ΡΠ·Π°Π½Π½ΠΎΠΉ Ρ ΠΎΠ±ΡΡΠ΅Π½ΠΈΠ΅ΠΌ, ΠΎΠΏΡΠ±Π»ΠΈΠΊΠΎΠ²Π°Π½Ρ Π² ΡΡΠ°ΡΡΠ΅: Π . Π. Dash, Π. Hochner & E. R. Kandel, Injection of cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation, Nature 345 (1990): 718β721.
ΠΡΠΊΡΡΡΠΈΠ΅ Π±Π΅Π»ΠΊΠ°-ΡΠ΅ΠΏΡΠ΅ΡΡΠΎΡΠ° Π°ΠΏΠ»ΠΈΠ·ΠΈΠΈ ΠΎΠΏΠΈΡΠ°Π½ΠΎ Π² ΡΡΠ°ΡΡΠ΅: D. Bartsch, Π. Ghirardi, P. A. Skehel, Π. A. Karl, S. P. Herder, Π. Chen, Π‘. Π. Bailey & E. R. Kandel, Aplysia CREB-2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change, Cell 83 (1995): 979β992.
Π Π½ΠΎΠ²ΠΎΠΌ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΌ ΠΌΠ΅ΡΠΎΠ΄Π΅ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΏΠ°ΠΌΡΡΠΈ Ρ Π΄ΡΠΎΠ·ΠΎΡΠΈΠ»Ρ ΡΠΌ.: Π’. Tully, Π’. Preat, S. Π‘. Boynton & Π. Del Vecchio, Genetic dissection of consolidated memory in Drosophila melanogaster, Cell 79 (1994): 35β47.
Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΡΡΡΠ°Ρ Π°, ΡΠΊΠ°Π·ΡΠ²Π°ΡΡΠΈΠ΅ Π½Π° ΡΠΎΠ»Ρ CREB-penpeccopa Π² ΠΏΠΎΠ΄Π°Π²Π»Π΅Π½ΠΈΠΈ Π΄ΠΎΠ»Π³ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΠΏΠ°ΠΌΡΡΠΈ, Π° CREB-Π°ΠΊΡΠΈΠ²Π°ΡΠΎΡΠ° β Π² Π΅Π΅ ΡΡΠΈΠ»Π΅Π½ΠΈΠΈ, ΠΎΠΏΡΠ±Π»ΠΈΠΊΠΎΠ²Π°Π½Ρ Π² ΡΡΠ°ΡΡΡΡ : J. Π‘. P. Yin, J. S. Wallach, Π. Del Vecchio, E. L. Wilder, H. Zhuo, W. G. Quinn & T. Tully, Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila, Cell 79 (1994): 49β58; J. C. P. Yin, M. Del Vecchio, H. Zhou & T. Tully, CREB as a memory modulator: Induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila. Cell 81 (1995): 107β115.
ΠΠ°Π½Π½ΡΠ΅ ΠΎ ΡΠ°Π±ΠΎΡΠ΅ CREB-Π±Π΅Π»ΠΊΠΎΠ² Ρ ΠΏΡΠ΅Π» ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ Π² ΡΡΠ°ΡΡΠ΅: D. Eisenhardt, A. Friedrich, N. Stollhoff, U. Muller, Π. Kress & R. Menzel, The AmCREB gene is an ortholog of the mammalian CREB/CREM family of transcription factors and encodes several splice variants in the honeybee brain, Insect Molecular Biol. 12 (2003): 373β382.
ΠΠ°Π½Π½ΡΠ΅ ΠΎ ΡΠΎΠ»ΠΈ CREB-Π±Π΅Π»ΠΊΠΎΠ² Π² ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ΅Π½Π½ΠΎΠΌ ΡΡΡΠ°Ρ Π΅ Ρ ΠΌΡΡΠ΅ΠΉ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ Π² ΡΡΠ°ΡΡΡΡ : Π . W. Frankland, S. A. Josselyn, S. G. Anag-n ΠΎ star as et AL., Consolidation of CS and US representations in associative fear conditioning, Hippocampus 14 (2004): 557β569 ΠΈ S. Kida, S. A. Josselyn, S. P. de Ortiz et al., CREB required for the stability of new and reactivated fear memories, Nature Neurosci.
ΠΠ°Π½Π½ΡΠ΅ ΠΎ ΡΠΎΠ»ΠΈ CREB-Π±Π΅Π»ΠΊΠΎΠ² Π² ΠΎΠ±ΡΡΠ΅Π½ΠΈΠΈ Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ Π² ΡΡΠ°ΡΡΡΡ : B. Π. Alarcon, G. Malleret, Π. Touzani, S. Vronskaya, S. Ishii, E. R. Kandel & A. Barco, Chromatin acetylation, memory, and LTP are impaired in Π‘ΠΠ +/ β mice: A model for the cognitive deficit in Rubinstein-Taybi Syndrome and its amelioration, Neuron 42 (2004): 947β959.
ΠΡΡΠ³ΠΈΠ΅ ΡΠ²Π΅Π΄Π΅Π½ΠΈΡ, ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Π½ΡΠ΅ Π² ΡΡΠΎΠΉ Π³Π»Π°Π²Π΅, ΠΏΠΎΡΠ΅ΡΠΏΠ½ΡΡΡ ΠΈΠ· ΡΠ»Π΅Π΄ΡΡΡΠΈΡ ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠ²:
Bailey, Π‘. Π., P. Montarolo, Π. Chen, E. R. Kandel & S. Schacher. Inhibitors of protein and RNA synthesis block structural changes that accompany long-term heterosynaptic plasticity in Aplysia. Neuron 9 (1992): 749β758.
Bartsch, D., A. Casadio, Π. A. Karl, P. Serodio & E. R. Kandel. CREB-i encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation. Cell 95 (1998): 211β223.
Bartsch, D., M. Ghirardi, A. Casadio, M. Giustetto, K. A. Karl, H. Zhu & E. R. Kandel. Enhancement of memory-related long-term facilitation by ApAF, a novel transcription factor that acts downstream from both CREB-i and CREB-2. Cell 103 (2000): 595β608.
Casadio, Π., Π. C. Martin, M. Giustetto, H. Zhu, M. Chen, D. Bartsch, C. H. Bailey & E. R. Kandel. A transient neuron-wide form ofCREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis. Cell 99 (1999)= 221β237.
Chain, D. G., A. Casadio, S. Schacher. A. N. Hegde. M. Valbrun, N. Yamamoto, A. L. Goldberg, D. Bartsch, E. R. Kandel & J. H. Schwartz. Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia. Neuron 22 (1999): 147β156.
Dale, N. 81 E. R. Kandel. L-glutamate may be the fast excitatory transmitter of Aplysia sensory neurons, Proc. Natl. Acad. Sci. USA 90 (1993): 7163β7167.
Glanzman, D. L, E. R. Kandel & S. Schacher. Target-dependent structural changes accompanying long-term synaptic facilitation in Aplysia neurons. Science 249 (1990): 799β802.
Kaang, B. K., E. R. Kandel & S. G. N. Grant. Activation of cAMP-responsive genes by stimuli that produce long-term facilitation in Aplysia sensory neurons. Neuron 10 (1993): 427β435.
Lorenz, K. Z. The Foundations of Ethology. New York: Springer Verlag, 1981.
Martin, K. C., D. Michael, J. C. Rose, M. Barad, A. Casadio, H. Zhu & E. R. Kandel. MAP kinase translocates into the nucleus of the presynaptic cell and is required for long-term facilitation in Aplysia. Neuron 18 (1997): 899β912.
Martin, Π. C., A. Casadio, H. Zhu, E. Yaping, J. Rose, C. H. Bailey, M. Chen & E. R. Kandel. Synapse-specific transcription-dependent long-term facilitation of the sensory to motor neuron connection in Aplysia: A function for local protein synthesis in memory storage. Cell 91 (1997): 927β938.
Mayford, Π., A. Barzilai, F. Keller, S. Schacher & E. R. Kandel. Modulation of an NCAM-related adhesion molecule with long-term synaptic plasticity in Aplysia. Science 256 (1992): 638β644.
Montarolo, P. G., P. Goelet, V. F. Castellucci, J. Morgan, E. R. Kandel & S. Schacher. A critical period for macromolecular synthesis in long-term heterosynaptic facilitation in Aplysia. Science 234 (1986): 1249β1254.
Montminy, M. R., K. A. Sevarino, J. A. Wagner, G. Mandel 8Β» R. H. Goodman. Identification of a cyclic-AMP-responsive element within the rat somatostatin gene. Proc. Natl. Acad. Sci. USA 83, no. 18 (1986): 6682β6686.
Prusiner, S. B. Prions. Les Prix Nobel/The Nobel Prizes, ed. Nobel Foundation. Stockholm: Almquist & Wiksell International, 1997.
Ray port, S. G. & S. Schacher. Synaptic plasticity in vitro: Cell culture of identified Aplysia neurons mediating short-term habituation and sensitization. J. Neurosci. 6 (1986): 759β763.
Schacher, S., V. F. Castellucci & E. R. Kandel. cAMP evokes longterm facilitation in Aplysia sensory neurons that requires new protein synthesis. Science 240 (1988): 1667β1669.
Si, Π., M. Giustetto, A. Etkin, R. Hsu, A. M. Janisiewicz, Π. C. MiniΠ°Ρi, J. H. Kim, H. Zhu &. E. R. Kandel. Aneuronaliso-form ofCPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in Aplysia. Cell 115 (2003): 893β904.
Si, K., S. Lindquist 81 E. R. Kandel . A neuronal isoform of the Aplysia CPEB has prion-like properties. Cell 115 (2003): 879β891.
Steward, O. & E. M. Schuman. Protein synthesis at synaptic sites on dendrites. Annu. Rev. Neurosci. 24 (2001): 299β325.
20. ΠΠΎΠ·Π²ΡΠ°ΡΠ΅Π½ΠΈΠ΅ ΠΊ ΡΠ»ΠΎΠΆΠ½ΠΎΠΉ ΠΏΠ°ΠΌΡΡΠΈ
ΠΠΈΡΠ΄ΠΆΠΈΠ½ΠΈΡ ΠΡΠ»Ρ ΠΏΠΈΡΠ°Π»Π° ΠΎ ΡΠ²ΠΎΠΈΡ Π²ΠΎΡΠΏΠΎΠΌΠΈΠ½Π°Π½ΠΈΡΡ ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈ Π² βΠΡΠ΅ΡΠΊΠ°Ρ ΠΎ ΠΏΡΠΎΡΠ»ΠΎΠΌβ (W. Woolf, Sketches of the Past), ΠΏΠ΅ΡΠ΅ΠΏΠ΅ΡΠ°ΡΠ°Π½Π½ΡΡ Π² ΠΊΠ½ΠΈΠ³Π΅: J. Schulkind, ed., Moments of Being (New York: Harcourt Brace, 1985), ΡΡΡ. 98, ΠΈ ΡΠΈΡΠΈΡΡΠ΅ΠΌΡΡ Π² ΠΊΠ½ΠΈΠ³Π΅: S. Nalbation, Memory in Literature: Rousseau to Neuroscience (New York: Palgrave Macmillan, 2003).